08/18/2017

A dosing error that would lead to underdosing of methotrexate was found on the following chemotherapy order template.

A dosing error that would lead to underdosing of methotrexate was found on the following chemotherapy order template. This error occurred on June 27, 2017 when the chemotherapy order templates were migrated into a new computer program. This template was republished with the correct dosing on August 17, 2017 when the error was discovered.

• HyperCVAD (Cyclophosphamide/VinCRIStine/DOXOrubicin/Dexamethasone + RiTUXimab (Cycle A) alternating with High-Dose Methotrexate/Cytarabine + RiTUXimab (Cycle B)
  • MCL17b – High-Dose Methotrexate/Cytarabine + RiTUXimab (Cycle B) Course
    • Correct dosing of methotrexate is as follows:
      • Methotrexate
        • 200 mg/m² over 2 hours on Day 1 followed by
        • 800 mg/m² IV continuous infusion over 22 hours on Day 1