03/16/2017

NCCN has published updates to the NCCN Guidelines® for Colon and Rectal Cancers.

NCCN has published updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines^®) for Colon and Rectal Cancers. The NCCN Guidelines^® for Rectal Cancer are currently available as Version 3.2017. The NCCN Guidelines for Colon Cancer are currently available as Version 2.2017.

Colon and Rectal Cancers:

• Unresectable Synchronous Liver and/or Lung Metastases (COL-6); Unresectable Metachronous Metastases (COL-11/REC-11); and Systemic Therapy for Advanced or Metastatic Disease (COL-C 6 of 10/REC-E 6 of 10)
  • Footnote modified: Evidence increasingly suggests that BRAF V600E mutation makes response to panitumumab or cetuximab, as single agents or in combination with cytotoxic chemotherapy, highly unlikely.

Colon Cancer:

• Unresectable Synchronous Liver and/or Lung Metastases (COL-6) and Systemic Therapy for Advanced or Metastatic Disease (COL-C 6 of 10)
  • The following footnote added: The panel defines the left side of the colon as splenic flexure to rectum. Evidence suggests that patients with tumors originating on the right side of the colon (hepatic flexure through cecum) are unlikely to respond to cetuximab and panitumumab in first-line therapy for metastatic disease. Data on the response to cetuximab and panitumumab in patients with primary tumors originating in the transverse colon (hepatic flexure to splenic flexure) are lacking.

*For your reference, the previous update (Version 2.2017) to the NCCN Guidelines for Rectal Cancer, published on December 22, 2016, is available at the following link: https://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf

*For your reference, the previous update (Version 1.2017) to the NCCN Guidelines for Colon Cancer, published on November 23, 2016, is available at the following link: https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf

For the complete updated versions of the NCCN Guidelines, NCCN Guidelines with NCCN Evidence Blocks™, the NCCN Drugs & Biologics Compendium (NCCN Compendium^®), the NCCN Biomarkers Compendium^®, the NCCN Chemotherapy Order Templates (NCCN Templates^®), and the NCCN Imaging Appropriate Use Criteria (NCCN Imaging AUC™), please visit NCCN.org.